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Sotorasib: First Approval | SpringerLink
Sotorasib: First Approval | SpringerLink

Sotorasib: Is Maximum Tolerated Dose Really the Issue at Hand? | Journal of  Clinical Oncology
Sotorasib: Is Maximum Tolerated Dose Really the Issue at Hand? | Journal of Clinical Oncology

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors | NEJM
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors | NEJM

Sotorasib Impresses in Advanced Pancreatic Cancer | MedPage Today
Sotorasib Impresses in Advanced Pancreatic Cancer | MedPage Today

Sotorasib for Lung Cancers with KRAS p.G12C Mutation | NEJM
Sotorasib for Lung Cancers with KRAS p.G12C Mutation | NEJM

Sotorasib Shows Early Activity Against KRAS G12C Mutant NSCLC - ILCN.org  (ILCN/WCLC)
Sotorasib Shows Early Activity Against KRAS G12C Mutant NSCLC - ILCN.org (ILCN/WCLC)

Sotorasib for Lung Cancers with KRAS p.G12C Mutation | NEJM
Sotorasib for Lung Cancers with KRAS p.G12C Mutation | NEJM

Similarities and differences among sotorasib and adagrasib (direct KRAS...  | Download Scientific Diagram
Similarities and differences among sotorasib and adagrasib (direct KRAS... | Download Scientific Diagram

Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry,  concurrent pathway alterations, and clinical outcomes | npj Precision  Oncology
Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes | npj Precision Oncology

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors | NEJM
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors | NEJM

Sotorasib for previously treated colorectal cancers with KRASG12C mutation  (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial -  The Lancet Oncology
Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial - The Lancet Oncology

Sotorasib Tablets
Sotorasib Tablets

Stephen V Liu, MD on Twitter: "#ESMO20 Overall, sotorasib showing clear  efficacy (RR 32.2%, DOR 10.9m, PFS 6.3m) and excellent safety profile.  Would have a clear role today in salvage setting. Good
Stephen V Liu, MD on Twitter: "#ESMO20 Overall, sotorasib showing clear efficacy (RR 32.2%, DOR 10.9m, PFS 6.3m) and excellent safety profile. Would have a clear role today in salvage setting. Good

Absorption, metabolism and excretion of [14C]-sotorasib in healthy male  subjects: characterization of metabolites and a minor albumin-sotorasib  conjugate | springermedizin.de
Absorption, metabolism and excretion of [14C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate | springermedizin.de

Why did FDA ask Amgen to add low-dose trial of Lumakras? < Pharma < Article  - KBR
Why did FDA ask Amgen to add low-dose trial of Lumakras? < Pharma < Article - KBR

Sotorasib for Lung Cancers with KRAS p.G12C Mutation | NEJM
Sotorasib for Lung Cancers with KRAS p.G12C Mutation | NEJM

Stephen V Liu, MD on Twitter: "#ESMO20 CodeBreak100 is a phase I  escalation/expansion trial of sotorasib monotherapy in KRAS G12C tumors.  Primary endpoint was safety. Escalation established preferred dose of 960mg  qday. #
Stephen V Liu, MD on Twitter: "#ESMO20 CodeBreak100 is a phase I escalation/expansion trial of sotorasib monotherapy in KRAS G12C tumors. Primary endpoint was safety. Escalation established preferred dose of 960mg qday. #

Dose Finding in Oncology: What is Impeding Coming of Age? | SpringerLink
Dose Finding in Oncology: What is Impeding Coming of Age? | SpringerLink

KRAS inhibitor sotorasib appears safe, achieves durable clinical benefit in  early trial | MD Anderson Cancer Center
KRAS inhibitor sotorasib appears safe, achieves durable clinical benefit in early trial | MD Anderson Cancer Center

Undruggable No More: KRAS Experts Review What is Known—and Unknown—About  This Challenging Alteration - ILCN.org (ILCN/WCLC)
Undruggable No More: KRAS Experts Review What is Known—and Unknown—About This Challenging Alteration - ILCN.org (ILCN/WCLC)

Dr. Antonio Calles 🫁🚭 on Twitter: "💥 Sotorasib vs docetaxel for  previously treated NSCLC with KRAS G12C mutation: CodeBreak200 phase IlI  study 😕 ORR 28.1% 😕 PFS 5.6 months (delta 1.1 month)
Dr. Antonio Calles 🫁🚭 on Twitter: "💥 Sotorasib vs docetaxel for previously treated NSCLC with KRAS G12C mutation: CodeBreak200 phase IlI study 😕 ORR 28.1% 😕 PFS 5.6 months (delta 1.1 month)

LUMYKRAS - Amgen.de
LUMYKRAS - Amgen.de

LUMAKRAS® Once Daily Oral Therapy | LUMAKRAS® (sotorasib)
LUMAKRAS® Once Daily Oral Therapy | LUMAKRAS® (sotorasib)

Data presented at ESMO strengthens concern that the labeled dose of  sotorasib is not optimal - The Cancer Letter
Data presented at ESMO strengthens concern that the labeled dose of sotorasib is not optimal - The Cancer Letter

LUMAKRAS® Once Daily Oral Therapy | LUMAKRAS® (sotorasib)
LUMAKRAS® Once Daily Oral Therapy | LUMAKRAS® (sotorasib)

Dose Optimization of Sotorasib: Is the US Food and Drug Administration  Sending a Message? | Journal of Clinical Oncology
Dose Optimization of Sotorasib: Is the US Food and Drug Administration Sending a Message? | Journal of Clinical Oncology